clinical tests

Rivaroxaban outperformed by VKAs for AF in rheumatic heart disease

Contrary to expectations, vitamin K antagonists (VKAs) reduced the risk of ischemic stroke and death compared with rivaroxaban, a factor Xa inhibitor (Xarelto, Janssen) in patients with rheumatic heart disease and atrial fibrillation, in the INVICTUS trial. Patients receiving a VKA, usually warfarin, had a 25% lower risk for the primary outcome – a composite …

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Researchers find ‘weak point’ in major SARS-CoV-2 variants

Researchers have discovered a “weak spot” on the spike protein of major SARS-CoV-2 variants, as well as a specific antibody fragment that attaches to it to neutralize the virus. This discovery could pave the way for the development of an effective antibody treatment against current and future strains of the virus. The study by Dhiraj …

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PET scan reveals best time for Alzheimer’s drug trials

A group from Montreal, Quebec studied the activity of the amyloid PET radiotracer in PET brain scans of a large group of patients with Alzheimer’s disease enrolled in clinical trials. The team found significant early activity in most patients considered negative for the disease and suggests moving the starting gate when it comes to testing …

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